KS
Biomedical Engineering
The University of Texas at Austin
Kushaan
Sharma
Kushaan Sharma
I build computational tools that turn physiological recordings into measurements you can trust.
My work sits where signal processing, medical imaging, and machine learning meet clinical questions: scoring sleep state from EEG and EMG in real time, generating and evaluating synthetic ECG, quantifying contraction in engineered heart tissue, measuring pancreatic fat distribution from 3D MRI, and building structured meshes from cardiovascular imaging. I currently hold research positions at the National Institutes of Health, the Broad Institute of MIT and Harvard, Boston Children's Hospital, UT Austin, and the Department of Veterans Affairs, and serve as CTO of Revio, a publishing-tools venture accepted to MIT Sandbox.
- Degree
- B.S. Biomedical Engineering
- Grade point average
- 4.00 / 4.00
- Expected graduation
- May 2028
- Goal
- M.D./Ph.D.
Research
6 positions · 2025 to present
Six positions across neuroscience, cardiology, imaging, simulation, and nanotechnology, five of them concurrent. The common thread is taking a physiological recording or scan that cannot be measured by hand at scale and building the software that measures it.
Current
Jun 2026 to Present
Research Fellow, NIH IRTA
National Institutes of Health, NIAAA · Laboratory for Integrative Neuroscience
Built a real-time sleep-scoring pipeline in Open Ephys that classifies EEG and EMG as it streams, across up to 16 animals at once. When the scorer calls NREM, the rig fires a TTL pulse and delivers optical stimulation, closing the loop between what the brain is doing and what the experiment does about it.
The surrounding infrastructure matters as much as the classifier: automated run logging, benchmark testing, and portable run folders, so a night of recording is reproducible rather than artisanal.
Open EphysTTL routingReal-time DAQClosed-loop optogeneticsPython
Current
Jun 2026 to Present
Machine Learning Research Intern, ML4H
The Broad Institute of MIT and Harvard
Building generative models that synthesize ECG waveforms, then evaluating the output on three fronts at once: whether it is clinically realistic, whether it protects the privacy of the patients it learned from, and whether it can genuinely expand a training set.
The longer-range question is whether synthetic cardiac signal is good enough to support patient digital-twin experiments.
Generative modelingPrivacy evaluationTensorFlowDigital twins
Current
Jan 2026 to Present
Part-time
Health Technician
U.S. Department of Veterans Affairs · San Francisco VA Health Care System
Generates high-quality structured hexahedral meshes from cardiovascular imaging data using TrueGrid, turning patient imaging into the structured geometry that computational simulation of blood flow and vessel mechanics requires.
TrueGridHexahedral meshingCardiovascular imagingStructured meshes
Current
Sep 2025 to Present
Project Lead, Pu Laboratory
Boston Children's Hospital · Harvard Medical School
Wrote the computer-vision and MATLAB signal-processing tools that turn video of engineered heart tissue into numbers (contractility, bending, and pacing response), replacing manual frame-by-frame scoring. That code is the measurement layer in a Nature Protocols manuscript now under review.
Separately developed EKG processing methods to detect atrial fibrillation and track heart-tissue movement. The work earned a merit-based research stipend.
MATLABOpenCVMotion trackingAtrial fibrillationhiPSC-CM
Current
Sep 2025 to Present
Project Lead, Virostko Laboratory
Dell Medical School and Oden Institute · UT Austin
Built a 3D MRI method that quantifies pancreatic fat as a function of distance from the organ surface, so fat distribution becomes a spatial measurement rather than a single whole-organ average. It supports studies of how that distribution shifts in diabetes and pancreatic cancer.
Manuscript in preparation; the method was submitted to the American Pancreatic Association.
3D segmentationQuantitative MRIPythonPancreas
Jul 2025 to Jan 2026
Part-time
Research Assistant, Nanoassembly Lab
Department of Biomedical Engineering · Cockrell School of Engineering, UT Austin
Analyzed how the N/P ratio affects the stability of DNA origami nanostructures, using qPCR degradation measurements to quantify how much intact structure survives under nuclease challenge. Listed on the resulting manuscript.
DNA origamiqPCRNanostructure stabilityWet lab
Leadership
2 positions · 2025 to present
Current
May 2026 to Present
Part-time
Data Coordinator
Perfect Pair · National Team · KushaanSharma@perfectpair.org
Maintains program data, organizes the key metrics, and surfaces the insights that strengthen outreach, operations, and impact measurement across the organization.
Currently supporting a campaign to raise $50,000 for senior citizens.
Data operationsImpact measurementNonprofit
Current
Nov 2025 to Present
Part-time
Chief Technology Officer
Revio · reviobeta.vercel.app
Building tooling that streamlines research paper preparation, formatting, and international publishing, so the mechanics of getting work published take less time away from the work itself.
Accepted to MIT Sandbox, MIT's innovation fund for student ventures.
MIT SandboxPublishing toolingTechnical leadership
Publications
3 manuscripts · 3 presentations
Diagnosing the Information Limits of In Vitro Drug Release from PLGA Microparticle Data
Pharmaceutics
Published
First author
Curated 321 PLGA formulations from 113 studies and 4,913 release observations, then showed that the formulation descriptors the field routinely reports do not carry enough information to predict drug release in a way that transfers to new formulations. A negative result worth publishing, because it tells the field what to measure next.
Generation of hiPSC-CMs in Scalable Suspension Cultures and Characterization Using SCPs and EHTs
Nature Protocols
Under review
Sixth author
Contributed the MATLAB signal-processing code that measures contractility in the engineered heart tissue platform, the step that converts the protocol's raw imaging into a quantitative readout.
ERVExplorer: A Curated Database of Experimentally Confirmed Endogenous Retroviruses
Genetics in Medicine Open
Published
Third author
Built a literature-checked database of endogenous retroviruses that resolves the disagreements between existing databases, with every entry traced back to experimental confirmation rather than inherited annotation.
Presentations
- American Pancreatic Association, submitted
- ACMG, 2025
- IFORE, 2024
Projects
github.com/Kushaan-SSSK
Most of the research above exists as running software. Two cardiac projects are in active development; the rest is public.
In progress
ECG AI Artifact
Active
Artifact-Robust ECG Image AI for Structural Heart Disease
Detects echocardiography-confirmed structural heart disease directly from realistic ECG images: paper printouts, scans, and smartphone photos, along with the skew, glare, and print artifacts those carry. Nothing requires a raw digital waveform at inference, so the model works on the form an ECG actually arrives in.
- Input
- Paper printouts, scans, phone photos
- Target
- Echo-confirmed structural heart disease
- Constraint
- No digital waveform at inference
AF Analysis
Active
Mouse EKG Atrial Fibrillation Detection
Detects atrial fibrillation in mouse EKG using HRV feature extraction and a Balanced Random Forest, validated against expert manual annotations. Recordings pass through a 3 Hz high-pass filter and sliding-window peak detection (10 s window, 2 s step) tuned for mouse physiology at 300 to 900 BPM. For paroxysmal files a window counts as AF only if at least 5 seconds overlap a known episode, which keeps boundary windows from being mislabeled.
- Features
- Time domain, Welch frequency bands, Poincaré nonlinear, plus prev/next temporal context
- Model
- Balanced Random Forest, leave-one-file-out CV, benchmarked against XGBoost and a soft-voting ensemble
- Selection
- Highest PR-AUC, threshold set for recall at or above 0.80
Repositories
MARS-publicPython
Mouse Automated Real-Time Scoring. Native Open Ephys processors that score EEG/EMG sleep state live, route TTL safely, and write portable run folders, plus an offline EDF analysis suite with a QC interface. Benchmarks at 0.969 offline accuracy and 95.65% real-time at 0.788 ms p95 inference.
plga-microparticles-datasetPython
Full reproduction of the Pharmaceutics analysis: grouped train/test splits that block leakage, Peppas-kinetics mechanism prediction, burst-release classification, Williams-plot applicability domain, and calibrated uncertainty. Fixed seeds, CPU only, runs in 5 to 15 minutes.
EHT-AnalysisMATLAB
The contractility toolchain from the Pu Lab. Quantifies engineered heart tissue contraction, post bending, and pacing response from video. This is the measurement code behind the Nature Protocols submission.
SID-EpidemicPython
A Susceptible-Infected-Dead epidemic model that simulates agents moving on a 2D grid, so transmission depends on where people actually are rather than on a well-mixed assumption.
heart-disease-predictionPython
Classical machine learning on clinical cardiac risk factors. The earliest of these repositories, and where the cardiac thread running through the Pu Lab and Broad work started.
Skills
Methods, languages, hardware
Signals
EEGEMGECG / EKGSleep scoringAtrial fibrillation detectionContractilitySpectral analysis
Imaging
Computer visionImage segmentationMRI / 3D quantificationMotion trackingOpenCV
Modeling
Machine learningDeep learningGenerative modelingStatistical modelingUncertainty quantificationScientific computing
Acquisition
Open EphysTTL routingReal-time DAQClosed-loop controlHardware programmingFusion 360
Languages
PythonMATLABC++JavaSQLJavaScript
Stack
Scikit-learnXGBoostTensorFlowPandasNumPyReactNode.jsFlaskPostgreSQLRAG systems
Certifications
CITI Human Research (Biomedical)CITI Data or Specimens OnlyCITI Conflicts of Interest
Wet lab
DNA origamiqPCRNanostructure stabilityDegradation assays
Spoken languages
EnglishHindiPunjabi
Honors
Research, collegiate, pre-college
Merit award
Merit-based research stipend, Pu Laboratory
Boston Children's Hospital · Harvard Medical School
Finalist
Biomedical Engineering Case Competition
Collegiate
First place
HOSA International Leadership Conference
International
Gold division
USA Computing Olympiad
USACO
National finalist
Technology Student Association
National
Where this is going
An M.D./Ph.D. in Biomedical Engineering, and a physician-scientist career building computational tools for physiological and imaging-based biomarkers. That is the measurement layer quantitative disease modeling depends on, and the clinic is where it has to hold up.
Research interests: computational biomedical engineering, physiological signal processing, medical imaging, and machine learning methods for quantitative disease modeling.