Biomedical Engineering
The University of Texas at Austin

Kushaan Sharma

I build computational tools that turn physiological recordings into measurements you can trust.

My work sits where signal processing, medical imaging, and machine learning meet clinical questions: scoring sleep state from EEG and EMG in real time, generating and evaluating synthetic ECG, quantifying contraction in engineered heart tissue, measuring pancreatic fat distribution from 3D MRI, and building structured meshes from cardiovascular imaging. I currently hold research positions at the National Institutes of Health, the Broad Institute of MIT and Harvard, Boston Children's Hospital, UT Austin, and the Department of Veterans Affairs, and serve as CTO of Revio, a publishing-tools venture accepted to MIT Sandbox.

Degree
B.S. Biomedical Engineering
Grade point average
4.00 / 4.00
Expected graduation
May 2028
Goal
M.D./Ph.D.

Research

6 positions · 2025 to present

Six positions across neuroscience, cardiology, imaging, simulation, and nanotechnology, five of them concurrent. The common thread is taking a physiological recording or scan that cannot be measured by hand at scale and building the software that measures it.

Current Jun 2026 to Present

Research Fellow, NIH IRTA

National Institutes of Health, NIAAA · Laboratory for Integrative Neuroscience

Built a real-time sleep-scoring pipeline in Open Ephys that classifies EEG and EMG as it streams, across up to 16 animals at once. When the scorer calls NREM, the rig fires a TTL pulse and delivers optical stimulation, closing the loop between what the brain is doing and what the experiment does about it.

The surrounding infrastructure matters as much as the classifier: automated run logging, benchmark testing, and portable run folders, so a night of recording is reproducible rather than artisanal.

Open EphysTTL routingReal-time DAQClosed-loop optogeneticsPython
Current Jun 2026 to Present

Machine Learning Research Intern, ML4H

The Broad Institute of MIT and Harvard

Building generative models that synthesize ECG waveforms, then evaluating the output on three fronts at once: whether it is clinically realistic, whether it protects the privacy of the patients it learned from, and whether it can genuinely expand a training set.

The longer-range question is whether synthetic cardiac signal is good enough to support patient digital-twin experiments.

Generative modelingPrivacy evaluationTensorFlowDigital twins
Current Jan 2026 to Present Part-time

Health Technician

U.S. Department of Veterans Affairs · San Francisco VA Health Care System

Generates high-quality structured hexahedral meshes from cardiovascular imaging data using TrueGrid, turning patient imaging into the structured geometry that computational simulation of blood flow and vessel mechanics requires.

TrueGridHexahedral meshingCardiovascular imagingStructured meshes
Current Sep 2025 to Present

Project Lead, Pu Laboratory

Boston Children's Hospital · Harvard Medical School

Wrote the computer-vision and MATLAB signal-processing tools that turn video of engineered heart tissue into numbers (contractility, bending, and pacing response), replacing manual frame-by-frame scoring. That code is the measurement layer in a Nature Protocols manuscript now under review.

Separately developed EKG processing methods to detect atrial fibrillation and track heart-tissue movement. The work earned a merit-based research stipend.

MATLABOpenCVMotion trackingAtrial fibrillationhiPSC-CM
Current Sep 2025 to Present

Project Lead, Virostko Laboratory

Dell Medical School and Oden Institute · UT Austin

Built a 3D MRI method that quantifies pancreatic fat as a function of distance from the organ surface, so fat distribution becomes a spatial measurement rather than a single whole-organ average. It supports studies of how that distribution shifts in diabetes and pancreatic cancer.

Manuscript in preparation; the method was submitted to the American Pancreatic Association.

3D segmentationQuantitative MRIPythonPancreas
Jul 2025 to Jan 2026 Part-time

Research Assistant, Nanoassembly Lab

Department of Biomedical Engineering · Cockrell School of Engineering, UT Austin

Analyzed how the N/P ratio affects the stability of DNA origami nanostructures, using qPCR degradation measurements to quantify how much intact structure survives under nuclease challenge. Listed on the resulting manuscript.

DNA origamiqPCRNanostructure stabilityWet lab

Leadership

2 positions · 2025 to present
Current May 2026 to Present Part-time

Data Coordinator

Perfect Pair · National Team · KushaanSharma@perfectpair.org

Maintains program data, organizes the key metrics, and surfaces the insights that strengthen outreach, operations, and impact measurement across the organization.

Currently supporting a campaign to raise $50,000 for senior citizens.

Data operationsImpact measurementNonprofit
Current Nov 2025 to Present Part-time

Chief Technology Officer

Revio · reviobeta.vercel.app

Building tooling that streamlines research paper preparation, formatting, and international publishing, so the mechanics of getting work published take less time away from the work itself.

Accepted to MIT Sandbox, MIT's innovation fund for student ventures.

MIT SandboxPublishing toolingTechnical leadership

Publications

3 manuscripts · 3 presentations

Diagnosing the Information Limits of In Vitro Drug Release from PLGA Microparticle Data

Pharmaceutics Published

Curated 321 PLGA formulations from 113 studies and 4,913 release observations, then showed that the formulation descriptors the field routinely reports do not carry enough information to predict drug release in a way that transfers to new formulations. A negative result worth publishing, because it tells the field what to measure next.

Generation of hiPSC-CMs in Scalable Suspension Cultures and Characterization Using SCPs and EHTs

Nature Protocols Under review

Contributed the MATLAB signal-processing code that measures contractility in the engineered heart tissue platform, the step that converts the protocol's raw imaging into a quantitative readout.

ERVExplorer: A Curated Database of Experimentally Confirmed Endogenous Retroviruses

Genetics in Medicine Open Published

Built a literature-checked database of endogenous retroviruses that resolves the disagreements between existing databases, with every entry traced back to experimental confirmation rather than inherited annotation.

Presentations
  • American Pancreatic Association, submitted
  • ACMG, 2025
  • IFORE, 2024

Projects

github.com/Kushaan-SSSK

Most of the research above exists as running software. Two cardiac projects are in active development; the rest is public.

In progress
ECG AI Artifact Active

Artifact-Robust ECG Image AI for Structural Heart Disease

Detects echocardiography-confirmed structural heart disease directly from realistic ECG images: paper printouts, scans, and smartphone photos, along with the skew, glare, and print artifacts those carry. Nothing requires a raw digital waveform at inference, so the model works on the form an ECG actually arrives in.

Input
Paper printouts, scans, phone photos
Target
Echo-confirmed structural heart disease
Constraint
No digital waveform at inference
AF Analysis Active

Mouse EKG Atrial Fibrillation Detection

Detects atrial fibrillation in mouse EKG using HRV feature extraction and a Balanced Random Forest, validated against expert manual annotations. Recordings pass through a 3 Hz high-pass filter and sliding-window peak detection (10 s window, 2 s step) tuned for mouse physiology at 300 to 900 BPM. For paroxysmal files a window counts as AF only if at least 5 seconds overlap a known episode, which keeps boundary windows from being mislabeled.

Features
Time domain, Welch frequency bands, Poincaré nonlinear, plus prev/next temporal context
Model
Balanced Random Forest, leave-one-file-out CV, benchmarked against XGBoost and a soft-voting ensemble
Selection
Highest PR-AUC, threshold set for recall at or above 0.80
Repositories

Skills

Methods, languages, hardware

Signals

EEGEMGECG / EKGSleep scoringAtrial fibrillation detectionContractilitySpectral analysis

Imaging

Computer visionImage segmentationMRI / 3D quantificationMotion trackingOpenCV

Modeling

Machine learningDeep learningGenerative modelingStatistical modelingUncertainty quantificationScientific computing

Acquisition

Open EphysTTL routingReal-time DAQClosed-loop controlHardware programmingFusion 360

Languages

PythonMATLABC++JavaSQLJavaScript

Stack

Scikit-learnXGBoostTensorFlowPandasNumPyReactNode.jsFlaskPostgreSQLRAG systems

Certifications

CITI Human Research (Biomedical)CITI Data or Specimens OnlyCITI Conflicts of Interest

Wet lab

DNA origamiqPCRNanostructure stabilityDegradation assays

Spoken languages

EnglishHindiPunjabi

Honors

Research, collegiate, pre-college
Merit award

Merit-based research stipend, Pu Laboratory

Boston Children's Hospital · Harvard Medical School
Finalist

Biomedical Engineering Case Competition

Collegiate
First place

HOSA International Leadership Conference

International
Gold division

USA Computing Olympiad

USACO
National finalist

Technology Student Association

National

Where this is going

An M.D./Ph.D. in Biomedical Engineering, and a physician-scientist career building computational tools for physiological and imaging-based biomarkers. That is the measurement layer quantitative disease modeling depends on, and the clinic is where it has to hold up.

Research interests: computational biomedical engineering, physiological signal processing, medical imaging, and machine learning methods for quantitative disease modeling.